I am calculating genotype probabilities for PrP gene in our local sheep breeds. I am using iterative allelic peeling with incomplete penetrance (Thallman et al., 2001a, 2001b) as implemented in the GenoProb program, written by Thallman. Yes, I am using his method since he was kind enough to share the software with me. Of course, the methods does what I need. I did a bit of research on the available methods and from what I see one can use the following for animal livestock pedigrees:
Fernández, S. A., Fernando, R. L., Guldbrandtsen, B., Totir, L. R. & Carriquiry, A. L. Sampling genotypes in large pedigrees with loops. Genetics Selection Evolution 33, 337-367 (2001). http://dx.doi.org/10.1051/gse:2001122
Henshall, J. M. and Tier, B. An algorithm for sampling descent graphs in large complex pedigrees efficiently. GR, 2003, 81(3):205-212. http://dx.doi.org/10.1017/S0016672303006232
Thallman, R. M. and Bennet, G. L. and Keele, J. W. and Kappes, S. M. Efficient computation of genotype probabilities for loci with many alleles: I. Allelic peeling. JAS, 2001a, 79(1):26-33. http://jas.fass.org/cgi/reprint/79/1/26
Thallman, R. M. and Bennet, G. L. and Keele, J. W. and Kappes, S. M. Efficient computation of genotype probabilities for loci with many alleles: II. Iterative method for large, complex pedigrees. JAS, 2001b, 79(1):34-44. http://jas.fass.org/cgi/reprint/79/1/34
van Arendonk, J. A. M. and Smith, C. and Kennedy, B. W. Method to estimate genotype probabilities at individual loci in farm livestock. TAG, 1989, 78:735-740.
- iterative peeling (see van Arendonk et al., 1989 and papers citing it!),
- Elston-Stewart iterative peeling (ESIP) sampler (Fernández et. al, 2001),
- descent graphs samplers (see Henshall and Tier, 2003) and
- allelic peeling (Thallman et al., 2001a, 2001b).
Fernández, S. A., Fernando, R. L., Guldbrandtsen, B., Totir, L. R. & Carriquiry, A. L. Sampling genotypes in large pedigrees with loops. Genetics Selection Evolution 33, 337-367 (2001). http://dx.doi.org/10.1051/gse:2001122
Henshall, J. M. and Tier, B. An algorithm for sampling descent graphs in large complex pedigrees efficiently. GR, 2003, 81(3):205-212. http://dx.doi.org/10.1017/S0016672303006232
Thallman, R. M. and Bennet, G. L. and Keele, J. W. and Kappes, S. M. Efficient computation of genotype probabilities for loci with many alleles: I. Allelic peeling. JAS, 2001a, 79(1):26-33. http://jas.fass.org/cgi/reprint/79/1/26
Thallman, R. M. and Bennet, G. L. and Keele, J. W. and Kappes, S. M. Efficient computation of genotype probabilities for loci with many alleles: II. Iterative method for large, complex pedigrees. JAS, 2001b, 79(1):34-44. http://jas.fass.org/cgi/reprint/79/1/34
van Arendonk, J. A. M. and Smith, C. and Kennedy, B. W. Method to estimate genotype probabilities at individual loci in farm livestock. TAG, 1989, 78:735-740.
No comments:
Post a Comment